PDF DatasheetHuman Lysine-specific demethylase 5A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Lysine-specific demethylase 5A based upon sequence from Human
Host: QP6257 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Lysine-specific demethylase 5A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6257.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Glu437 – Arg603
Amino Acid Sequence: EYALSGWNLN NMPVLEQSVL AHINVDISGM KVPWLYVGMC FSSFCWHIED HWSYSINYLH WGEPKTWYGV PSHAAEQLEE VMRELAPELF ESQPDLLHQL VTIMNPNVLM EHGVPVYRTN QCAGEFVVTF PRAYHSGFNQ GYNFAEAVNF CTADWLPIGR QCVNHYR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Lysine-specific demethylase 5A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Lysine-specific demethylase 5A Protein General Information | |
|---|---|
| Alternate Names | |
| RBBP-2, RBP2, RBBP2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | KDM5A |
| Entrez Gene ID | 5927 |
| Ensemble Gene ID | ENSG00000073614 |
| RefSeq Protein Accession(s) | NP_001036068.1 |
| RefSeq mRNA Accession(s) | NM_001042603.2 |
| UniProt ID(s) | P29375 |
| UniGene ID(s) | Hs.76272 |
| HGNC ID(s) | HGNC:9886 |
| COSMIC ID Link(s) | KDM5A |
| KEGG Gene ID(s) | hsa:5927 |
| PharmGKB ID(s) | PA34250 |
| General Description of Recombinant Human Lysine-specific demethylase 5A Protein. | |
| Histone dethylase that specifically dethylates ‘Lys-4’ of histone H3, thereby playing a central role in histone code. Does not dethylate histone H3 ‘Lys-9’, H3 ‘Lys-27’, H3 ‘Lys-36’, H3 ‘Lys-79’ or H4 ‘Lys-20’. Dethylates trimethylated and dimethylated but not monomethylated H3 ‘Lys-4’. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone dethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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