PDF DatasheetMouse KEAP1 / INRF2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant KEAP1 / INRF2 based upon sequence from Mouse
Host: QP6259 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) KEAP1 / INRF2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6259.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Cys624
Amino Acid Sequence: MQPEPKLSGA PRSSQFLPLW SKCPEGAGDA VMYASTECKA EVTPSQDGNR TFSYTLEDHT KQAFGVMNEL RLSQQLCDVT LQVKYEDIPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISVGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCTELH QRAREYIYMH FGEVAKQEEF FNLSHCQLAT LISRDDLNVR CESEVFHACI DWVKYDCPQR RFYVQALLRA VRCHALTPRF LQTQLQKCEI LQADARCKDY LVQIFQELTL HKPTQAVPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSNG SWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCASMS VPRNRIGVGV IDGHIYAVGG SHGCIHHSSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI TPMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM RHHRSALGIT VHQGKIYVLG GYDGHTFLDS VECYDPDSDT WSEVTRMTSG RSGVGVAVTM EPCRKQIDQQ NCTC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse KEAP1 / INRF2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse KEAP1 / INRF2 Protein General Information | |
|---|---|
| Alternate Names | |
| KEAP1, INRF2, INrf2, KLHL19 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Keap1 |
| Entrez Gene ID | 50868 |
| Ensemble Gene ID | ENSMUSG00000003308 |
| RefSeq Protein Accession(s) | NP_001103775.1 |
| RefSeq mRNA Accession(s) | NM_001110305.1, NM_001110306.1, NM_001110307.1, NM_016679.4 |
| UniProt ID(s) | Q9Z2X8 |
| UniGene ID(s) | Mm.248266 |
| COSMIC ID Link(s) | Keap1 |
| KEGG Gene ID(s) | mmu:50868 |
| General Description of Recombinant Mouse KEAP1 / INRF2 Protein. | |
| Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.