PDF DatasheetHuman LIPA Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant LIPA based upon sequence from Human
Host: QP6311 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) LIPA, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6311.
Bioactivity Data: Untested
Full Length? Full Length of Mature Protein
Expression Region: Ser22 – Gln399
Amino Acid Sequence: SGGKLTAVDP ETNMNVSEII SYWGFPSEEY LVETEDGYIL CLNRIPHGRK NHSDKGPKPV VFLQHGLLAD SSNWVTNLAN SSLGFILADA GFDVWMGNSR GNTWSRKHKT LSVSQDEFWA FSYDEMAKYD LPASINFILN KTGQEQVYYV GHSQGTTIGF IAFSQIPELA KRIKMFFALG PVASVAFCTS PMAKLGRLPD HLIKDLFGDK EFLPQSAFLK WLGTHVCTHV ILKELCGNLC FLLCGFNERN LNMSRVDVYT THSPAGTSVQ NMLHWSQAVK FQKFQAFDWG SSAKNYFHYN QSYPPTYNVK DMLVPTAVWS GGHDWLADVY DVNILLTQIT NLVFHESIPE WEHLDFIWGL DAPWRLYNKI INLMRKYQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human LIPA Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human LIPA Protein General Information | |
|---|---|
| Alternate Names | |
| LAL, CESD, Lysosomal acid lipase/cholesteryl ester hydrola | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LIPA |
| Entrez Gene ID | 3988 |
| Ensemble Gene ID | ENSG00000107798 |
| RefSeq Protein Accession(s) | NP_000226.2 |
| RefSeq mRNA Accession(s) | NM_000235.3, NM_001127605.2, NM_001288979.1 |
| UniProt ID(s) | P38571 |
| UniGene ID(s) | Hs.643030 |
| HGNC ID(s) | HGNC:6617 |
| COSMIC ID Link(s) | LIPA |
| KEGG Gene ID(s) | hsa:3988 |
| PharmGKB ID(s) | PA30391 |
| General Description of Recombinant Human LIPA Protein. | |
| Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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