PDF DatasheetMouse LOXL2 / Lysyl oxidase homolog 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant LOXL2 / Lysyl oxidase homolog 2 based upon sequence from Mouse
Host: QP6317 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) LOXL2 / Lysyl oxidase homolog 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6317.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gln26 – Gln776
Amino Acid Sequence: QYEGWPYQLQ YPEYFQQPAP EHHQRQVPSD VVKIQVRLAG QKRKHNEGRV EVYYEGQWGT VCDDDFSIHA AHVVCRQVGY VEAKSWAASS SYGPGEGPIW LDNIYCTGKE STLASCSSNG WGVTDCKHTE DVGVVCSEKR IPGFKFDNSL INQIESLNIQ VEDIRIRPIL SAFRHRKPVT EGYVEVKEGK AWKQICNKHW TAKNSHVVCG MFGFPAEKTY NPKAYKTFAS RRKLRYWKFS MNCTGTEAHI SSCKLGPSVT RDPVKNATCE NGQPAVVSCV PSQIFSPDGP SRFRKAYKPE QPLVRLRGGA QVGEGRVEVL KNGEWGTICD DKWDLVSASV VCRELGFGTA KEAITGSRLG QGIGPIHLNE VQCTGTEKSI IDCKFNTESQ GCNHEEDAGV RCNIPIMGFQ KKVRLNGGRN PYEGRVEVLT ERNGSLVWGT VCGQNWGIVE AMVVCRQLGL GFASNAFQET WYWHGNIFAN NVVMSGVKCS GTELSLAHCR HDEEVACPEG GVRFGAGVAC SETAPDLVLN AEIVQQTAYL EDRPMSLLQC AMEENCLSAS AVHTDPTRGH RRLLRFSSQI HNNGQSDFRP KNGRHAWIWH DCHRHYHSME VFTYYDLLSL NGTKVAEGHK ASFCLEDTEC EGDIQKSYEC ANFGEQGITM GCWDMYRHDI DCQWIDITDV PPGDYLFQVV INPNYEVPES DFSNNIMKCR SRYDGYRIWM YNCHVGGAFS EETEQKFEHF SGLLNNQLSV Q
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse LOXL2 / Lysyl oxidase homolog 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse LOXL2 / Lysyl oxidase homolog 2 Protein General Information | |
|---|---|
| Alternate Names | |
| LOXL2, Lysyl oxidase homolog 2, 9430067E15Rik, 4930526G11Rik, 1110004B06Rik | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Loxl2 |
| Entrez Gene ID | 94352 |
| Ensemble Gene ID | ENSMUSG00000034205 |
| RefSeq Protein Accession(s) | NP_201582.2 |
| RefSeq mRNA Accession(s) | NM_033325.2, XM_006519747.2 |
| UniProt ID(s) | P58022 |
| UniGene ID(s) | Mm.116714 |
| COSMIC ID Link(s) | Loxl2 |
| KEGG Gene ID(s) | mmu:94352 |
| General Description of Recombinant Mouse LOXL2 / Lysyl oxidase homolog 2 Protein. | |
| Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in Extracellular domain matrix, promotes cross-linking of Extracellular domain matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated ‘Lys-4’ of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (T) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3 . Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.1 Publication | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.