PDF DatasheetHuman LRP4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant LRP4 based upon sequence from Human
Host: QP6320 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) LRP4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6320.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Tyr1747 – Val1905
Amino Acid Sequence: YRHKKSKFTD PGMGNLTYSN PSYRTSTQEV KIEAIPKPAM YNQLCYKKEG GPDHNYTKEK IKIVEGICLL SGDDAEWDDL KQLRSSRGGL LRDHVCMKTD TVSIQASSGS LDDTETEQLL QEEQSECSSV HTAATPERRG SLPDTGWKHE RKLSSESQV
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human LRP4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human LRP4 Protein General Information | |
|---|---|
| Alternate Names | |
| LRP10, SOST2, CLSS, LRP-4, MEGF7, CMS17, Low-density lipoprotein receptor-related protein | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LRP4 |
| Entrez Gene ID | 4038 |
| Ensemble Gene ID | ENSG00000134569 |
| RefSeq Protein Accession(s) | NP_002325.2 |
| RefSeq mRNA Accession(s) | NM_002334.3 |
| UniProt ID(s) | O75096 |
| UniGene ID(s) | Hs.4930 |
| HGNC ID(s) | HGNC:6696 |
| COSMIC ID Link(s) | LRP4 |
| KEGG Gene ID(s) | hsa:4038 |
| PharmGKB ID(s) | PA30454 |
| General Description of Recombinant Human LRP4 Protein. | |
| Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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