PDF DatasheetHuman p38 delta / MAPK13 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant p38 delta / MAPK13 based upon sequence from Human
Host: QP6339 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) p38 delta / MAPK13, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6339.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu365
Amino Acid Sequence: MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR SGMKL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human p38 delta / MAPK13 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human p38 delta / MAPK13 Protein General Information | |
|---|---|
| Alternate Names | |
| p38 delta, MAPK13, p38delta, SAPK4, MAPK 13, PRKM13, MAPK-13 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MAPK13 |
| Entrez Gene ID | 5603 |
| Ensemble Gene ID | ENSG00000156711 |
| RefSeq Protein Accession(s) | NP_002745.1 |
| RefSeq mRNA Accession(s) | NM_002754.4 |
| UniProt ID(s) | O15264 |
| UniGene ID(s) | Hs.178695 |
| HGNC ID(s) | HGNC:6875 |
| COSMIC ID Link(s) | MAPK13 |
| KEGG Gene ID(s) | hsa:5603 |
| PharmGKB ID(s) | PA30620 |
| General Description of Recombinant Human p38 delta / MAPK13 Protein. | |
| Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by Extracellular domain stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal rodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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