PDF DatasheetHuman Mannan-binding lectin serine protease 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Mannan-binding lectin serine protease 1 based upon sequence from Human
Host: QP6347 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Mannan-binding lectin serine protease 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6347.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: His20 – Asn699
Amino Acid Sequence: HTVELNNMFG QIQSPGYPDS YPSDSEVTWN ITVPDGFRIK LYFMHFNLES SYLCEYDYVK VETEDQVLAT FCGRETTDTE QTPGQEVVLS PGSFMSITFR SDFSNEERFT GFDAHYMAVD VDECKEREDE ELSCDHYCHN YIGGYYCSCR FGYILHTDNR TCRVECSDNL FTQRTGVITS PDFPNPYPKS SECLYTIELE EGFMVNLQFE DIFDIEDHPE VPCPYDYIKI KVGPKVLGPF CGEKAPEPIS TQSHSVLILF HSDNSGENRG WRLSYRAAGN ECPELQPPVH GKIEPSQAKY FFKDQVLVSC DTGYKVLKDN VEMDTFQIEC LKDGTWSNKI PTCKIVDCRA PGELEHGLIT FSTRNNLTTY KSEIKYSCQE PYYKMLNNNT GIYTCSAQGV WMNKVLGRSL PTCLPVCGLP KFSRKLMARI FNGRPAQKGT TPWIAMLSHL NGQPFCGGSL LGSSWIVTAA HCLHQSLDPE DPTLRDSDLL SPSDFKIILG KHWRLRSDEN EQHLGVKHTT LHPQYDPNTF ENDVALVELL ESPVLNAFVM PICLPEGPQQ EGAMVIVSGW GKQFLQRFPE TLMEIEIPIV DHSTCQKAYA PLKKKVTRDM ICAGEKEGGK DACAGDSGGP MVTLNRERGQ WYLVGTVSWG DDCGKKDRYG VYSYIHHNKD WIQRVTGVRN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Mannan-binding lectin serine protease 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Mannan-binding lectin serine protease 1 Protein General Information | |
|---|---|
| Alternate Names | |
| 3MC1, MAP1, MASP, MASP3, CRARF1, RaRF, CRARF, MAp44, PRSS5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MASP1 |
| Entrez Gene ID | 5648 |
| Ensemble Gene ID | ENSG00000127241 |
| RefSeq Protein Accession(s) | NP_001027019.1 |
| RefSeq mRNA Accession(s) | NM_001031849.2, NM_001879.5, NM_139125.3, XM_017006872.1 |
| UniProt ID(s) | P48740 |
| UniGene ID(s) | Hs.89983 |
| HGNC ID(s) | HGNC:6901 |
| COSMIC ID Link(s) | MASP1 |
| KEGG Gene ID(s) | hsa:5648 |
| PharmGKB ID(s) | PA30644 |
| General Description of Recombinant Human Mannan-binding lectin serine protease 1 Protein. | |
| Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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