PDF DatasheetHuman DNA replication licensing factor MCM2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA replication licensing factor MCM2 based upon sequence from Human
Host: QP6349 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA replication licensing factor MCM2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6349.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Phe904
Amino Acid Sequence: AESSESFTMA SSPAQRRRGN DPLTSSPGRS SRRTDALTSS PGRDLPPFED ESEGLLGTEG PLEEEEDGEE LIGDGMERDY RAIPELDAYE AEGLALDDED VEELTASQRE AAERAMRQRD REAGRGLGRM RRGLLYDSDE EDEERPARKR RQVERATEDG EEDEEMIESI ENLEDLKGHS VREWVSMAGP RLEIHHRFKN FLRTHVDSHG HNVFKERISD MCKENRESLV VNYEDLAARE HVLAYFLPEA PAELLQIFDE AALEVVLAMY PKYDRITNHI HVRISHLPLV EELRSLRQLH LNQLIRTSGV VTSCTGVLPQ LSMVKYNCNK CNFVLGPFCQ SQNQEVKPGS CPECQSAGPF EVNMEETIYQ NYQRIRIQES PGKVAAGRLP RSKDAILLAD LVDSCKPGDE IELTGIYHNN YDGSLNTANG FPVFATVILA NHVAKKDNKV AVGELTDEDV KMITSLSKDQ QIGEKIFASI APSIYGHEDI KRGLALALFG GEPKNPGGKH KVRGDINVLL CGDPGTAKSQ FLKYIEKVSS RAIFTTGQGA SAVGLTAYVQ RHPVSREWTL EAGALVLADR GVCLIDEFDK MNDQDRTSIH EAMEQQSISI SKAGIVTSLQ ARCTVIAAAN PIGGRYDPSL TFSENVDLTE PIISRFDILC VVRDTVDPVQ DEMLARFVVG SHVRHHPSNK EEEGLANGSA AEPAMPNTYG VEPLPQEVLK KYIIYAKERV HPKLNQMDQD KVAKMYSDLR KESMATGSIP ITVRHIESMI RMAEAHARIH LRDYVIEDDV NMAIRVMLES FIDTQKFSVM RSMRKTFARY LSFRRDNNEL LLFILKQLVA EQVTYQRNRF GAQQDTIEVP EKDLVDKARQ INIHNLSAFY DSELFRMNKF SHDLKRKMIL QQF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human DNA replication licensing factor MCM2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA replication licensing factor MCM2 Protein General Information | |
|---|---|
| Alternate Names | |
| CDCL1, cdc19, BM28, D3S3194, CCNL1, DFNA70, MITOTIN | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MCM2 |
| Entrez Gene ID | 4171 |
| Ensemble Gene ID | ENSG00000073111 |
| RefSeq Protein Accession(s) | NP_004517.2 |
| RefSeq mRNA Accession(s) | NM_004526.3 |
| UniProt ID(s) | P49736 |
| UniGene ID(s) | Hs.477481 |
| HGNC ID(s) | HGNC:6944 |
| COSMIC ID Link(s) | MCM2 |
| KEGG Gene ID(s) | hsa:4171 |
| PharmGKB ID(s) | PA164742061 |
| General Description of Recombinant Human DNA replication licensing factor MCM2 Protein. | |
| Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ‘once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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