PDF DatasheetHuman METAP2 / MAP2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant METAP2 / MAP2 based upon sequence from Human
Host: QP6355 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) METAP2 / MAP2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6355.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Tyr478
Amino Acid Sequence: AGVEEVAASG SHLNGDLDPD DREEGAASTA EEAAKKKRRK KKKSKGPSAA GEQEPDKESG ASVDEVARQL ERSALEDKER DEDDEDGDGD GDGATGKKKK KKKKKRGPKV QTDPPSVPIC DLYPNGVFPK GQECEYPPTQ DGRTAAWRTT SEEKKALDQA SEEIWNDFRE AAEAHRQVRK YVMSWIKPGM TMIEICEKLE DCSRKLIKEN GLNAGLAFPT GCSLNNCAAH YTPNAGDTTV LQYDDICKID FGTHISGRII DCAFTVTFNP KYDTLLKAVK DATNTGIKCA GIDVRLCDVG EAIQEVMESY EVEIDGKTYQ VKPIRNLNGH SIGQYRIHAG KTVPIVKGGE ATRMEEGEVY AIETFGSTGK GVVHDDMECS HYMKNFDVGH VPIRLPRTKH LLNVINENFG TLAFCRRWLD RLGESKYLMA LKNLCDLGIV DPYPPLCDIK GSYTAQFEHT ILLRPTCKEV VSRGDDY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human METAP2 / MAP2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human METAP2 / MAP2 Protein General Information | |
|---|---|
| Alternate Names | |
| METAP2, MAP2, A930035J23Rik, Amp2, AL024412, Mnpep, 4930584B20Rik, AU014659, p67eIF2, AI047573, p67 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | METAP2 |
| Entrez Gene ID | 10988 |
| Ensemble Gene ID | ENSG00000111142 |
| RefSeq Protein Accession(s) | NP_001304111.1 |
| RefSeq mRNA Accession(s) | NM_001317182.1, NM_001317183.1, NM_001330246.1, NM_006838.3 |
| UniProt ID(s) | P50579 |
| UniGene ID(s) | Hs.444986 |
| HGNC ID(s) | HGNC:16672 |
| COSMIC ID Link(s) | METAP2 |
| KEGG Gene ID(s) | hsa:10988 |
| PharmGKB ID(s) | PA30765 |
| General Description of Recombinant Human METAP2 / MAP2 Protein. | |
| Cotranslationally roves the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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