PDF DatasheetHuman Myeloid leukemia factor 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Myeloid leukemia factor 1 based upon sequence from Human
Host: QP6364 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Myeloid leukemia factor 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6364.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Lys268
Amino Acid Sequence: MFRMLNSSFE DDPFFSESIL AHRENMRQMI RSFSEPFGRD LLSISDGRGR AHNRRGHNDG EDSLTHTDVS SFQTMDQMVS NMRNYMQKLE RNFGQLSVDP NGHSFCSSSV MTYSKIGDEP PKVFQASTQT RRAPGGIKET RKAMRDSDSG LEKMAIGHHI HDRAHVIKKS KNKKTGDEEV NQEFINMNES DAHAFDEEWQ SEVLKYKPGR HNLGNTRMRS VGHENPGSRE LKRREKPQQS PAIEHGRRSN VLGDKLHIKG SSVKSNKK
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Myeloid leukemia factor 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Myeloid leukemia factor 1 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MLF1 |
| Entrez Gene ID | 4291 |
| Ensemble Gene ID | ENSG00000178053 |
| RefSeq Protein Accession(s) | NP_001123628.1 |
| RefSeq mRNA Accession(s) | NM_001130156.2, NM_001130157.2, NM_001195432.1, NM_001195433.1, NM_001195434.1, NM_022443.4, XM_005247480.2, XM_011512852.2, XM_011512853.2 |
| UniProt ID(s) | P58340 |
| UniGene ID(s) | Hs.85195 |
| HGNC ID(s) | HGNC:7125 |
| COSMIC ID Link(s) | MLF1 |
| KEGG Gene ID(s) | hsa:4291 |
| PharmGKB ID(s) | PA30843 |
| General Description of Recombinant Human Myeloid leukemia factor 1 Protein. | |
| Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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