PDF DatasheetHuman Collagenase 3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Collagenase 3 based upon sequence from Human
Host: QP6367 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Collagenase 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6367.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Tyr104 – Cys471
Amino Acid Sequence: YNVFPRTLKW SKMNLTYRIV NYTPDMTHSE VEKAFKKAFK VWSDVTPLNF TRLHDGIADI MISFGIKEHG DFYPFDGPSG LLAHAFPPGP NYGGDAHFDD DETWTSSSKG YNLFLVAAHE FGHSLGLDHS KDPGALMFPI YTYTGKSHFM LPDDDVQGIQ SLYGPGDEDP NPKHPKTPDK CDPSLSLDAI TSLRGETMIF KDRFFWRLHP QQVDAELFLT KSFWPELPNR IDAAYEHPSH DLIFIFRGRK FWALNGYDIL EGYPKKISEL GLPKEVKKIS AAVHFEDTGK TLLFSGNQVW RYDDTNHIMD KDYPRLIEED FPGIGDKVDA VYEKNGYIYF FNGPIQFEYS IWSNRIVRVM PANSILWC
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Collagenase 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Collagenase 3 Protein General Information | |
|---|---|
| Alternate Names | |
| CLG3, MMP-13, MDST, MANDP1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MMP13 |
| Entrez Gene ID | 4322 |
| Ensemble Gene ID | ENSG00000137745 |
| RefSeq Protein Accession(s) | NP_002418.1 |
| RefSeq mRNA Accession(s) | NM_002427.3 |
| UniProt ID(s) | P45452 |
| UniGene ID(s) | Hs.2936 |
| HGNC ID(s) | HGNC:7159 |
| COSMIC ID Link(s) | MMP13 |
| KEGG Gene ID(s) | hsa:4322 |
| PharmGKB ID(s) | PA30871 |
| General Description of Recombinant Human Collagenase 3 Protein. | |
| Plays a role in the degradation of Extracellular domain matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue rodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal bryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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