PDF DatasheetHuman Matrix metalloproteinase-14 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Matrix metalloproteinase-14 based upon sequence from Human
Host: QP6368 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Matrix metalloproteinase-14, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6368.
Bioactivity Data: Untested
Full Length? Full Length of Mature Protein
Expression Region: Tyr112 – Val582
Amino Acid Sequence: YAIQGLKWQH NEITFCIQNY TPKVGEYATY EAIRKAFRVW ESATPLRFRE VPYAYIREGH EKQADIMIFF AEGFHGDSTP FDGEGGFLAH AYFPGPNIGG DTHFDSAEPW TVRNEDLNGN DIFLVAVHEL GHALGLEHSS DPSAIMAPFY QWMDTENFVL PDDDRRGIQQ LYGGESGFPT KMPPQPRTTS RPSVPDKPKN PTYGPNICDG NFDTVAMLRG EMFVFKERWF WRVRNNQVMD GYPMPIGQFW RGLPASINTA YERKDGKFVF FKGDKHWVFD EASLEPGYPK HIKELGRGLP TDKIDAALFW MPNGKTYFFR GNKYYRFNEE LRAVDSEYPK NIKVWEGIPE SPRGSFMGSD EVFTYFYKGN KYWKFNNQKL KVEPGYPKSA LRDWMGCPSG GRPDEGTEEE TEVIIIEVDE EGGGAVSAAA VVLPVLLLLL VLAVGLAVFF FRRHGTPRRL LYCQRSLLDK V
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Matrix metalloproteinase-14 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Matrix metalloproteinase-14 Protein General Information | |
|---|---|
| Alternate Names | |
| MT-MMP, WNCHRS, MT-MMP 1, MMP-14, MT1-MMP, MMP-X1, MT1MMP, MTMMP1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MMP14 |
| Entrez Gene ID | 4323 |
| Ensemble Gene ID | ENSG00000157227 |
| RefSeq Protein Accession(s) | NP_004986.1 |
| RefSeq mRNA Accession(s) | NM_004995.3 |
| UniProt ID(s) | P50281 |
| UniGene ID(s) | Hs.2399 |
| HGNC ID(s) | HGNC:7160 |
| COSMIC ID Link(s) | MMP14 |
| KEGG Gene ID(s) | hsa:4323 |
| PharmGKB ID(s) | PA30872 |
| General Description of Recombinant Human Matrix metalloproteinase-14 Protein. | |
| Ses to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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