PDF DatasheetRat MMP-2 / CLG4A Protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant MMP-2 / CLG4A Protein based upon sequence from Rat
Host: QP6369 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) MMP-2 / CLG4A Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6369.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Tyr110 – Cys662
Amino Acid Sequence: YNFFPRKPKW DKNQITYRII GYTPDLDPET VDDAFARALK VWSDVTPLRF SRIHDGEADI MINFGRWEHG DGYPFDGKDG LLAHAFAPGT GVGGDSHFDD DELWTLGEGQ VVRVKYGNAD GEYCKFPFLF NGREYSSCTD TGRSDGFLWC STTYNFEKDG KYGFCPHEAL FTMGGNGDGQ PCKFPFRFQG TSYNSCTTEG RTDGYRWCGT TEDYDRDKKY GFCPETAMST VGGNSEGAPC VFPFTFLGNK YESCTSAGRS DGKVWCATTT NYDDDRKWGF CPDQGYSLFL VAAHEFGHAM GLEHSQDPGA LMAPIYTYTK NFRLSNDDIK GIQELYGPSP DADTDTGTGP TPTLGPVTPE ICKQDIVFDG IAQIRGEIFF FKDRFIWRTV TPRDKPTGPL LVATFWPELP EKIDAVYEAP QEEKAVFFAG NEYWVYSAST LERGYPKPLT SLGLPPDVQQ VDAAFNWSKN KKTYIFSGDK FWRYNEVKKK MDPGFPKLIA DSWNAIPDNL DAVVDLQGGG HSYFFKGAYY LKLENQSLKS VKFGSIKSDW LGC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat MMP-2 / CLG4A Protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat MMP-2 / CLG4A Protein Protein General Information | |
|---|---|
| Alternate Names | |
| MMP-2, CLG4A Protein, CLG4, CLG4A, MONA, MMP-2, MMP-II, TBE-1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Mmp2 |
| Entrez Gene ID | 81686 |
| RefSeq Protein Accession(s) | NP_112316.2 |
| RefSeq mRNA Accession(s) | NM_031054.2 |
| UniProt ID(s) | P33436 |
| UniGene ID(s) | Rn.6422 |
| COSMIC ID Link(s) | Mmp2 |
| KEGG Gene ID(s) | rno:81686 |
| General Description of Recombinant Rat MMP-2 / CLG4A Protein Protein. | |
| Ubiquitinous metalloproteinase that is involved in diverse functions such as rodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading Extracellular domain matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues .PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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