PDF DatasheetHuman MUSK Kinase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant MUSK Kinase based upon sequence from Human
Host: QP6395 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) MUSK Kinase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6395.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Leu24 – Thr495
Amino Acid Sequence: LPKAPVITTP LETVDALVEE VATFMCAVES YPQPEISWTR NKILIKLFDT RYSIRENGQL LTILSVEDSD DGIYCCTANN GVGGAVESCG ALQVKMKPKI TRPPINVKII EGLKAVLPCT TMGNPKPSVS WIKGDSPLRE NSRIAVLESG SLRIHNVQKE DAGQYRCVAK NSLGTAYSKV VKLEVEVFAR ILRAPESHNV TFGSFVTLHC TATGIPVPTI TWIENGNAVS SGSIQESVKD RVIDSRLQLF ITKPGLYTCI ATNKHGEKFS TAKAAATISI AEWSKPQKDN KGYCAQYRGE VCNAVLAKDA LVFLNTSYAD PEEAQELLVH TAWNELKVVS PVCRPAAEAL LCNHIFQECS PGVVPTPIPI CREYCLAVKE LFCAKEWLVM EEKTHRGLYR SEMHLLSVPE CSKLPSMHWD PTACARLPHL DYNKENLKTF PPMTSSKPSV DIPNLPSSSS SSFSVSPTYS MT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human MUSK Kinase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human MUSK Kinase Protein General Information | |
|---|---|
| Alternate Names | |
| MUSK Kinase, CMS9, FADS | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MUSK |
| Entrez Gene ID | 4593 |
| Ensemble Gene ID | ENSG00000030304 |
| RefSeq Protein Accession(s) | NP_001159752.1 |
| RefSeq mRNA Accession(s) | NM_001166280.1, NM_001166281.1, NM_005592.3 |
| UniProt ID(s) | O15146 |
| UniGene ID(s) | Hs.521653 |
| HGNC ID(s) | HGNC:7525 |
| COSMIC ID Link(s) | MUSK |
| KEGG Gene ID(s) | hsa:4593 |
| PharmGKB ID(s) | PA31326 |
| General Description of Recombinant Human MUSK Kinase Protein. | |
| Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle . Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic mbrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to mbranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous syst by mediating cholinergic responses, synaptic plasticity and mory formation .1 Publication | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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