PDF DatasheetHuman Nanos homolog 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Nanos homolog 2 based upon sequence from Human
Host: QP6402 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Nanos homolog 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6402.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Arg138
Amino Acid Sequence: MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL GAPGANGGLG TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV CGATGDQAHT LKYCPLNGGQ QSLYRRSGRN SAGRRVKR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Nanos homolog 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Nanos homolog 2 Protein General Information | |
|---|---|
| Alternate Names | |
| ZC2HC12B, NOS2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NANOS2 |
| Entrez Gene ID | 339345 |
| Ensemble Gene ID | ENSG00000188425 |
| RefSeq Protein Accession(s) | NP_001025032.1 |
| RefSeq mRNA Accession(s) | NM_001029861.2 |
| UniProt ID(s) | P60321 |
| UniGene ID(s) | Hs.434218 |
| HGNC ID(s) | HGNC:23292 |
| COSMIC ID Link(s) | NANOS2 |
| KEGG Gene ID(s) | hsa:339345 |
| PharmGKB ID(s) | PA134909776 |
| General Description of Recombinant Human Nanos homolog 2 Protein. | |
| Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the fale fate. Represses the fale fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for preiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial st cell population. Not essential for the assbly of P-bodies but is required for the maintenance of their normal state . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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