PDF DatasheetHuman Neuroglobin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Neuroglobin based upon sequence from Human
Host: QP6418 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Neuroglobin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6418.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Glu151
Amino Acid Sequence: MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Neuroglobin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Neuroglobin Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NGB |
| Entrez Gene ID | 58157 |
| Ensemble Gene ID | ENSG00000165553 |
| RefSeq Protein Accession(s) | NP_067080.1 |
| RefSeq mRNA Accession(s) | NM_021257.3 |
| UniProt ID(s) | Q9NPG2 |
| UniGene ID(s) | Hs.274363 |
| HGNC ID(s) | HGNC:14077 |
| COSMIC ID Link(s) | NGB |
| KEGG Gene ID(s) | hsa:58157 |
| PharmGKB ID(s) | PA31612 |
| General Description of Recombinant Human Neuroglobin Protein. | |
| Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell mbranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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