PDF DatasheetHuman NF-kappa-B-repressing factor Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NF-kappa-B-repressing factor based upon sequence from Human
Host: QP6421 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NF-kappa-B-repressing factor, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6421.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ile4 – Gln688
Amino Acid Sequence: ILQMAEGIDI GEMPSYDLVL SKPSKGQKRH LSTCDGQNPP KKQAGSKFHA RPRFEPVHFV ASSSKDERQE DPYGPQTKEV NEQTHFASMP RDIYQDYTQD SFSIQDGNSQ YCDSSGFILT KDQPVTANMY FDSGNPAPST TSQQANSQST PEPSPSQTFP ESVVAEKQYF IEKLTATIWK NLSNPEMTSG SDKINYTYML TRCIQACKTN PEYIYAPLKE IPPADIPKNK KLLTDGYACE VRCQNIYLTT GYAGSKNGSR DRATELAVKL LQKRIEVRVV RRKFKHTFGE DLVVCQIGMS SYEFPPALKP PEDLVVLGKD ASGQPIFNAS AKHWTNFVIT ENANDAIGIL NNSASFNKMS IEYKYEMMPN RTWRCRVFLQ DHCLAEGYGT KKTSKHAAAD EALKILQKTQ PTYPSVKSSQ CHTGSSPRGS GKKKDIKDLV VYENSSNPVC TLNDTAQFNR MTVEYVYERM TGLRWKCKVI LESEVIAEAV GVKKTVKYEA AGEAVKTLKK TQPTVINNLK KGAVEDVISR NEIQGRSAEE AYKQQIKEDN IGNQLLRKMG WTGGGLGKSG EGIREPISVK EQHKREGLGL DVERVNKIAK RDIEQIIRNY ARSESHTDLT FSRELTNDER KQIHQIAQKY GLKSKSHGVG HDRYLVVGRK RRKEDLLDQL KQEGQVGHYE LVMPQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human NF-kappa-B-repressing factor Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NF-kappa-B-repressing factor Protein General Information | |
|---|---|
| Alternate Names | |
| NRF, ITBA4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NKRF |
| Entrez Gene ID | 55922 |
| Ensemble Gene ID | ENSG00000186416 |
| RefSeq Protein Accession(s) | NP_001166958.1 |
| RefSeq mRNA Accession(s) | NM_001173487.1, NM_001173488.1, NM_017544.3, XM_011531365.2 |
| UniProt ID(s) | O15226 |
| UniGene ID(s) | Hs.437084 |
| HGNC ID(s) | HGNC:19374 |
| COSMIC ID Link(s) | NKRF |
| KEGG Gene ID(s) | hsa:55922 |
| PharmGKB ID(s) | PA134990602 |
| General Description of Recombinant Human NF-kappa-B-repressing factor Protein. | |
| Interacts with a specific negative regulatory elent (NRE) 5′-AATTCCTCTGA-3′ to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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