PDF DatasheetHuman NR2F6 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NR2F6 based upon sequence from Human
Host: QP6434 protein expressed in E.coli, Mammal..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NR2F6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6434.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln404
Amino Acid Sequence: MAMVTGGWGG PGGDTNGVDK AGGYPRAAED DSASPPGAAS DAEPGDEERP GLQVDCVVCG DKSSGKHYGV FTCEGCKSFF KRSIRRNLSY TCRSNRDCQI DQHHRNQCQY CRLKKCFRVG MRKEAVQRGR IPHSLPGAVA ASSGSPPGSA LAAVASGGDL FPGQPVSELI AQLLRAEPYP AAAGRFGAGG GAAGAVLGID NVCELAARLL FSTVEWARHA PFFPELPVAD QVALLRLSWS ELFVLNAAQA ALPLHTAPLL AAAGLHAAPM AAERAVAFMD QVRAFQEQVD KLGRLQVDSA EYGCLKAIAL FTPDACGLSD PAHVESLQEK AQVALTEYVR AQYPSQPQRF GRLLLRLPAL RAVPASLISQ LFFMRLVGKT PIETLIRDML LSGSTFNWPY GSGQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human NR2F6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NR2F6 Protein General Information | |
|---|---|
| Alternate Names | |
| ERBAL2, EAR2, EAR-2, Nuclear receptor subfamily 2 group F member | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NR2F6 |
| Entrez Gene ID | 2063 |
| Ensemble Gene ID | ENSG00000160113 |
| RefSeq Protein Accession(s) | NP_005225.2 |
| RefSeq mRNA Accession(s) | NM_005234.3 |
| UniProt ID(s) | P10588 |
| UniGene ID(s) | Hs.466148 |
| HGNC ID(s) | HGNC:7977 |
| COSMIC ID Link(s) | NR2F6 |
| KEGG Gene ID(s) | hsa:2063 |
| PharmGKB ID(s) | PA31760 |
| General Description of Recombinant Human NR2F6 Protein. | |
| Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5′-AGGTCA-3′ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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