PDF DatasheetHuman NRG-3 / Neuregulin-3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant NRG-3 / Neuregulin-3 based upon sequence from Human
Host: QP6437 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) NRG-3 / Neuregulin-3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6437.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Met1 – Gln360
Amino Acid Sequence: MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPTDHLGIEF MESEEVYQRQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human NRG-3 / Neuregulin-3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human NRG-3 / Neuregulin-3 Protein General Information | |
|---|---|
| Alternate Names | |
| NRG-3, Neuregulin-3, pro-NRG3, HRG3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | NRG3 |
| Entrez Gene ID | 10718 |
| Ensemble Gene ID | ENSG00000185737 |
| RefSeq Protein Accession(s) | NP_001010848.2 |
| RefSeq mRNA Accession(s) | NM_001010848.3, NM_001165973.1, XM_005269444.4 |
| UniProt ID(s) | P56975 |
| UniGene ID(s) | Hs.125119 |
| HGNC ID(s) | HGNC:7999 |
| COSMIC ID Link(s) | NRG3 |
| KEGG Gene ID(s) | hsa:10718 |
| PharmGKB ID(s) | PA31778 |
| General Description of Recombinant Human NRG-3 / Neuregulin-3 Protein. | |
| Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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