PDF DatasheetHuman OLR1 / LOX1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant OLR1 / LOX1 based upon sequence from Human
Host: QP6452 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) OLR1 / LOX1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6452.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Met58 – Gln273
Amino Acid Sequence: MQLSQVSDLL TQEQANLTHQ KKKLEGQISA RQQAEEASQE SENELKEMIE TLARKLNEKS KEQMELHHQN LNLQETLKRV ANCSAPCPQD WIWHGENCYL FSSGSFNWEK SQEKCLSLDA KLLKINSTAD LDFIQQAISY SSFPFWMGLS RRNPSYPWLW EDGSPLMPHL FRVRGAVSQT YPSGTCAYIQ RGAVYAENCI LAAFSICQKK ANLRAQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human OLR1 / LOX1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human OLR1 / LOX1 Protein General Information | |
|---|---|
| Alternate Names | |
| OLR1, LOX1, SLOX1, CLEC8A, SCARE1, LOXIN, LOX1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | OLR1 |
| Entrez Gene ID | 4973 |
| Ensemble Gene ID | ENSG00000173391 |
| RefSeq Protein Accession(s) | NP_001166103.1 |
| RefSeq mRNA Accession(s) | NM_001172632.1, NM_001172633.1, NM_002543.3 |
| UniProt ID(s) | P78380 |
| UniGene ID(s) | Hs.412484 |
| HGNC ID(s) | HGNC:8133 |
| COSMIC ID Link(s) | OLR1 |
| KEGG Gene ID(s) | hsa:4973 |
| PharmGKB ID(s) | PA31920 |
| General Description of Recombinant Human OLR1 / LOX1 Protein. | |
| Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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