PDF DatasheetHuman Polyadenylate-binding protein 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Polyadenylate-binding protein 1 based upon sequence from Human
Host: QP6461 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Polyadenylate-binding protein 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6461.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Arg370
Amino Acid Sequence: MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR SLGYAYVNFQ QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY GFVHFETQEA AERAIEKMNG MLLNDRKVFV GRFKSRKERE AELGARAKEF TNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT KPLYVALAQR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Polyadenylate-binding protein 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Polyadenylate-binding protein 1 Protein General Information | |
|---|---|
| Alternate Names | |
| PABP1, PABPC2, PAB1, PABP, PABPL1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PABPC1 |
| Entrez Gene ID | 26986 |
| Ensemble Gene ID | ENSG00000070756 |
| RefSeq Protein Accession(s) | NP_002559.2 |
| RefSeq mRNA Accession(s) | NM_002568.3, XM_005250861.2 |
| UniProt ID(s) | P11940 |
| UniGene ID(s) | Hs.387804 |
| HGNC ID(s) | HGNC:8554 |
| COSMIC ID Link(s) | PABPC1 |
| KEGG Gene ID(s) | hsa:26986 |
| PharmGKB ID(s) | PA32880 |
| General Description of Recombinant Human Polyadenylate-binding protein 1 Protein. | |
| Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in Cytoplasmic domain regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to Cytoplasmic domain RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the Cytoplasmic domain deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing prature stop codons; for the recognition of prature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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