PDF DatasheetMouse Pituitary homeobox 3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Pituitary homeobox 3 based upon sequence from Mouse
Host: QP6496 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Pituitary homeobox 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6496.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Val302
Amino Acid Sequence: MEFGLLGEAE ARSPALSLSD AGTPHPPLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERSQQAELCK GGFAAPLGGL VPPYEEVYPG YSYGNWPPKA LAPPLAAKTF PFAFNSVNVG PLASQPVFSP PSSIAASMVP SAAAAPGTVP GPGALQGLGG APPGLAPAAV SSGAVSCPYA SAAAAAAAAA SSPYVYRDPC NSSLASLRLK AKQHASFSYP AVPGPPPAAN LSPCQYAVER PV
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Mouse Pituitary homeobox 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse Pituitary homeobox 3 Protein General Information | |
|---|---|
| Alternate Names | |
| ak, Ptx3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Pitx3 |
| Entrez Gene ID | 18742 |
| Ensemble Gene ID | ENSMUSG00000025229 |
| RefSeq Protein Accession(s) | NP_032878.1 |
| RefSeq mRNA Accession(s) | NM_008852.4 |
| UniProt ID(s) | O35160 |
| UniGene ID(s) | Mm.6255 |
| COSMIC ID Link(s) | Pitx3 |
| KEGG Gene ID(s) | mmu:18742 |
| General Description of Recombinant Mouse Pituitary homeobox 3 Protein. | |
| Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the tporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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