PDF DatasheetHuman POLR3K Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant POLR3K based upon sequence from Human
Host: QP6512 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) POLR3K, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6512.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asp108
Amino Acid Sequence: MLLFCPGCGN GLIVEEGQRC HRFSCNTCPY VHNITRKVTN RKYPKLKEVD DVLGGAAAWE NVDSTAESCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA QCGHRWRD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human POLR3K Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human POLR3K Protein General Information | |
|---|---|
| Alternate Names | |
| RPC11, RPC10, C11, My010, RPC12.5, C11-RNP3, DNA-directed RNA polymerase III subunit RPC | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | POLR3K |
| Entrez Gene ID | 51728 |
| Ensemble Gene ID | ENSG00000161980 |
| RefSeq Protein Accession(s) | NP_057394.3 |
| RefSeq mRNA Accession(s) | NM_016310.4 |
| UniProt ID(s) | Q9Y2Y1 |
| UniGene ID(s) | Hs.632223 |
| HGNC ID(s) | HGNC:14121 |
| COSMIC ID Link(s) | POLR3K |
| KEGG Gene ID(s) | hsa:51728 |
| PharmGKB ID(s) | PA33521 |
| General Description of Recombinant Human POLR3K Protein. | |
| DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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