PDF DatasheetHuman PPARG Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PPARG based upon sequence from Human
Isoform: Isoform 1
Host: QP6518 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PPARG, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6518.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 1
Expression Region: Met1 – His477
Amino Acid Sequence: MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL SVMEDHSHSF DIKPFTTVDF SSISTPHYED IPFTRTDPVV ADYKYDLKLQ EYQSAIKVEP ASPPYYSEKT QLYNKPHEEP SNSLMAIECR VCGDKASGFH YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE QSKEVAIRIF QGCQFRSVEA VQEITEYAKS IPGFVNLDLN DQVTLLKYGV HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK LNHPESSQLF AKLLQKMTDL RQIVTEH
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PPARG Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PPARG Protein General Information | |
|---|---|
| Alternate Names | |
| PPARgamma, NR1C3, PPARG1, CIMT1, GLM1, PPARG2, Peroxisome proliferator-activated receptor gam | |
| Molecular Weight | |
| Isoform 1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PPARG |
| Entrez Gene ID | 5468 |
| Ensemble Gene ID | ENSG00000132170 |
| RefSeq Protein Accession(s) | NP_005028.4 |
| RefSeq mRNA Accession(s) | NM_005037.5, NM_015869.4, NM_138711.3, NM_138712.3, XM_011533841.2 |
| UniProt ID(s) | P37231 |
| UniGene ID(s) | Hs.162646 |
| HGNC ID(s) | HGNC:9236 |
| COSMIC ID Link(s) | PPARG |
| KEGG Gene ID(s) | hsa:5468 |
| PharmGKB ID(s) | PA281 |
| General Description of Recombinant Human PPARG Protein. | |
| Nuclear receptor that binds peroxisome proliferators such as hypolipidic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elents (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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