PDF DatasheetHuman PPM1A / PP2CA / PP2C-alpha Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PPM1A / PP2CA / PP2C-alpha based upon sequence from Human
Host: QP6519 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PPM1A / PP2CA / PP2C-alpha, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6519.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gly1 – Trp382
Amino Acid Sequence: GAFLDKPKME KHNAQGQGNG LRYGLSSMQG WRVEMEDAHT AVIGLPSGLE SWSFFAVYDG HAGSQVAKYC CEHLLDHITN NQDFKGSAGA PSVENVKNGI RTGFLEIDEH MRVMSEKKHG ADRSGSTAVG VLISPQHTYF INCGDSRGLL CRNRKVHFFT QDHKPSNPLE KERIQNAGGS VMIQRVNGSL AVSRALGDFD YKCVHGKGPT EQLVSPEPEV HDIERSEEDD QFIILACDGI WDVMGNEELC DFVRSRLEVT DDLEKVCNEV VDTCLYKGSR DNMSVILICF PNAPKVSPEA VKKEAELDKY LECRVEEIIK KQGEGVPDLV HVMRTLASEN IPSLPPGGEL ASKRNVIEAV YNRLNPYKND DTDSTSTDDM W
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PPM1A / PP2CA / PP2C-alpha Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PPM1A / PP2CA / PP2C-alpha Protein General Information | |
|---|---|
| Alternate Names | |
| PPM1A, PP2CA, PP2C-alpha, AI427932, MPPa-1, 2900017D14Rik, AU017636, 2310003C21Rik, MMPa-2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PPM1A |
| Entrez Gene ID | 5494 |
| Ensemble Gene ID | ENSG00000100614 |
| RefSeq Protein Accession(s) | NP_066283.1 |
| RefSeq mRNA Accession(s) | NM_021003.4, NM_177951.2, NM_177952.2, XM_005267779.1, XM_005267781.1, XM_011536878.1, XM_011536879.2, XM_011536880.2, XM_011536881.2, XM_011536882.2, XM_011536883.1, XM_011536884.1, XM_017021384.1, XM_017021385.1, XM_017021386.1, XM_017021387.1 |
| UniProt ID(s) | P35813 |
| UniGene ID(s) | Hs.130036 |
| HGNC ID(s) | HGNC:9275 |
| COSMIC ID Link(s) | PPM1A |
| KEGG Gene ID(s) | hsa:5494 |
| PharmGKB ID(s) | PA33603 |
| General Description of Recombinant Human PPM1A / PP2CA / PP2C-alpha Protein. | |
| Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.