PDF DatasheetHuman Protein phosphatase 1B Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein phosphatase 1B based upon sequence from Human
Host: QP6520 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein phosphatase 1B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6520.
Bioactivity Data: Untested
Full Length? Full Length of Isoform Beta-X
Expression Region: Ser2 – Ile192
Amino Acid Sequence: SIVLVCFSNA PKVSDEAVKK DSELDKHLES RVEEIMEKSG EEGMPDLAHV MRILSAENIP NLPPGGGLAG KRNVIEAVYS RLNPHRESDG ASDEAEESGS QGKLVEALRQ MRINHRGNYR QLLEEMLTSY RLAKVEGEES PAEPAATATS SNSDAGNPVT MQESHTESES GLAELDSSNE DAGTKMSGEK I
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Protein phosphatase 1B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein phosphatase 1B Protein General Information | |
|---|---|
| Alternate Names | |
| PP2C-beta, PP2CBETA, PP2CB, PP2C-beta-X, PPC2BETAX | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PPM1B |
| Entrez Gene ID | 5495 |
| Ensemble Gene ID | ENSG00000138032 |
| RefSeq Protein Accession(s) | NP_001028729.1 |
| RefSeq mRNA Accession(s) | NM_001033557.2, NM_002706.5, NM_177968.3, NM_177969.3 |
| UniProt ID(s) | O75688 |
| UniGene ID(s) | Hs.416769 |
| HGNC ID(s) | HGNC:9276 |
| COSMIC ID Link(s) | PPM1B |
| KEGG Gene ID(s) | hsa:5495 |
| PharmGKB ID(s) | PA33604 |
| General Description of Recombinant Human Protein phosphatase 1B Protein. | |
| Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at ‘Ser-172’. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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