PDF DatasheetHuman PPP1CB Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PPP1CB based upon sequence from Human
Host: QP6522 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PPP1CB, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6522.
Bioactivity Data: Untested
Full Length? Full Length of Mature Protein
Expression Region: Ala2 – Arg327
Amino Acid Sequence: ADGELNVDSL ITRLLEVRGC RPGKIVQMTE AEVRGLCIKS REIFLSQPIL LELEAPLKIC GDIHGQYTDL LRLFEYGGFP PEANYLFLGD YVDRGKQSLE TICLLLAYKI KYPENFFLLR GNHECASINR IYGFYDECKR RFNIKLWKTF TDCFNCLPIA AIVDEKIFCC HGGLSPDLQS MEQIRRIMRP TDVPDTGLLC DLLWSDPDKD VQGWGENDRG VSFTFGADVV SKFLNRHDLD LICRAHQVVE DGYEFFAKRQ LVTLFSAPNY CGEFDNAGGM MSVDETLMCS FQILKPSEKK AKYQYGGLNS GRPVTPPRTA NPPKKR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PPP1CB Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PPP1CB Protein General Information | |
|---|---|
| Alternate Names | |
| PP1B, HEL-S-80p, PP1beta, PPP1CD, PP-1B, Serine/threonine-protein phosphatase PP1-beta catalytic subun | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PPP1CB |
| Entrez Gene ID | 5500 |
| Ensemble Gene ID | ENSG00000213639 |
| RefSeq Protein Accession(s) | NP_002700.1 |
| RefSeq mRNA Accession(s) | NM_002709.2, NM_206876.1 |
| UniProt ID(s) | P62140 |
| UniGene ID(s) | Hs.702907 |
| HGNC ID(s) | HGNC:9282 |
| COSMIC ID Link(s) | PPP1CB |
| KEGG Gene ID(s) | hsa:5500 |
| PharmGKB ID(s) | PA33610 |
| General Description of Recombinant Human PPP1CB Protein. | |
| Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the ‘Ser-418’ residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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