PDF DatasheetHuman PRAME Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PRAME based upon sequence from Human
Host: QP6524 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PRAME, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6524.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn509
Amino Acid Sequence: MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR ELFPPLFMAA FDGRHSQTLK AMVQAWPFTC LPLGVLMKGQ HLHLETFKAV LDGLDVLLAQ EVRPRRWKLQ VLDLRKNSHQ DFWTVWSGNR ASLYSFPEPE AAQPMTKKRK VDGLSTEAEQ PFIPVEVLVD LFLKEGACDE LFSYLIEKVK RKKNVLRLCC KKLKIFAMPM QDIKMILKMV QLDSIEDLEV TCTWKLPTLA KFSPYLGQMI NLRRLLLSHI HASSYISPEK EEQYIAQFTS QFLSLQCLQA LYVDSLFFLR GRLDQLLRHV MNPLETLSIT NCRLSEGDVM HLSQSPSVSQ LSVLSLSGVM LTDVSPEPLQ ALLERASATL QDLVFDECGI TDDQLLALLP SLSHCSQLTT LSFYGNSISI SALQSLLQHL IGLSNLTHVL YPVPLESYED IHGTLHLERL AYLHARLREL LCELGRPSMV WLSANPCPHC GDRTFYDPEP ILCPCFMPN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PRAME Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PRAME Protein General Information | |
|---|---|
| Alternate Names | |
| OIP-4, CT130, MAPE, OIP4, Melanoma antigen preferentially expressed in tumo | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PRAME |
| Entrez Gene ID | 23532 |
| Ensemble Gene ID | ENSG00000185686 |
| RefSeq Protein Accession(s) | NP_001278644.1 |
| RefSeq mRNA Accession(s) | NM_001291715.1, NM_001291716.1, NM_001291717.1, NM_001291719.1, NM_001318126.1, NM_001318127.1, NM_006115.4, NM_206953.2, NM_206954.2, NM_206955.2, NM_206956.2 |
| UniProt ID(s) | P78395 |
| UniGene ID(s) | Hs.30743 |
| HGNC ID(s) | HGNC:9336 |
| COSMIC ID Link(s) | PRAME |
| KEGG Gene ID(s) | hsa:23532 |
| PharmGKB ID(s) | PA33698 |
| General Description of Recombinant Human PRAME Protein. | |
| Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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