PDF DatasheetRat PRNP / Prion Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PRNP / Prion based upon sequence from Rat
Host: QP6532 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) PRNP / Prion, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6532.
Bioactivity Data: Untested
Full Length? Full Length of Mature Protein
Expression Region: Gly29 – Ser231
Amino Acid Sequence: GGWNTGGSRY PGQGSPGGNR YPPQSGGTWG QPHGGGWGQP HGGGWGQPHG GGWGQPHGGG WSQGGGTHNQ WNKPSKPKTN LKHVAGAAAA GAVVGGLGGY MLGSAMSRPM LHFGNDWEDR YYRENMYRYP NQVYYRPVDQ YSNQNNFVHD CVNITIKQHT VTTTTKGENF TETDVKMMER VVEQMCVTQY QKESQAYYDG RRS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat PRNP / Prion Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat PRNP / Prion Protein General Information | |
|---|---|
| Alternate Names | |
| PRNP, Prion, CD230, PrP, PrP27-30, PrPc, GSS, p27-30, ASCR, KURU, CJD, PRIP, AltPrP, PrP33-35C | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Prnp |
| Entrez Gene ID | 24686 |
| Ensemble Gene ID | ENSRNOG00000021259 |
| RefSeq Protein Accession(s) | NP_036763.1 |
| RefSeq mRNA Accession(s) | NM_012631.2, XM_006235062.3 |
| UniProt ID(s) | P13852 |
| UniGene ID(s) | Rn.3936 |
| COSMIC ID Link(s) | Prnp |
| KEGG Gene ID(s) | rno:24686 |
| General Description of Recombinant Rat PRNP / Prion Protein. | |
| May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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