PDF DatasheetHuman PSAP / Prosaposin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PSAP / Prosaposin based upon sequence from Human
Host: QP6540 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PSAP / Prosaposin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6540.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser311 – Thr391
Amino Acid Sequence: SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV VDTYGSSILS ILLEEVSPEL VCSMLHLCSG T
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PSAP / Prosaposin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PSAP / Prosaposin Protein General Information | |
|---|---|
| Alternate Names | |
| PSAP, Prosaposin, SGP-1, AI037048 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PSAP |
| Entrez Gene ID | 5660 |
| Ensemble Gene ID | ENSG00000197746 |
| RefSeq Protein Accession(s) | NP_001035930.1 |
| RefSeq mRNA Accession(s) | NM_001042465.2, NM_001042466.2, NM_002778.3 |
| UniProt ID(s) | P07602 |
| UniGene ID(s) | Hs.523004 |
| HGNC ID(s) | HGNC:9498 |
| COSMIC ID Link(s) | PSAP |
| KEGG Gene ID(s) | hsa:5660 |
| PharmGKB ID(s) | PA33845 |
| General Description of Recombinant Human PSAP / Prosaposin Protein. | |
| Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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