PDF DatasheetHuman PTGS2 / COX2 / PGHS-2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PTGS2 / COX2 / PGHS-2 based upon sequence from Human
Host: QP6551 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PTGS2 / COX2 / PGHS-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6551.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala18 – Ser601
Amino Acid Sequence: ANPCCSHPCQ NRGVCMSVGF DQYKCDCTRT GFYGENCSTP EFLTRIKLFL KPTPNTVHYI LTHFKGFWNV VNNIPFLRNA IMSYVLTSRS HLIDSPPTYN ADYGYKSWEA FSNLSYYTRA LPPVPDDCPT PLGVKGKKQL PDSNEIVEKL LLRRKFIPDP QGSNMMFAFF AQHFTHQFFK TDHKRGPAFT NGLGHGVDLN HIYGETLARQ RKLRLFKDGK MKYQIIDGEM YPPTVKDTQA EMIYPPQVPE HLRFAVGQEV FGLVPGLMMY ATIWLREHNR VCDVLKQEHP EWGDEQLFQT SRLILIGETI KIVIEDYVQH LSGYHFKLKF DPELLFNKQF QYQNRIAAEF NTLYHWHPLL PDTFQIHDQK YNYQQFIYNN SILLEHGITQ FVESFTRQIA GRVAGGRNVP PAVQKVSQAS IDQSRQMKYQ SFNEYRKRFM LKPYESFEEL TGEKEMSAEL EALYGDIDAV ELYPALLVEK PRPDAIFGET MVEVGAPFSL KGLMGNVICS PAYWKPSTFG GEVGFQIINT ASIQSLICNN VKGCPFTSFS VPDPELIKTV TINASSSRSG LDDINPTVLL KERS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PTGS2 / COX2 / PGHS-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PTGS2 / COX2 / PGHS-2 Protein General Information | |
|---|---|
| Alternate Names | |
| PTGS2, COX2, PGHS-2, GRIPGHS, PHS-2, PGHS-2, COX2, PGG/HS, COX-2, hCox-2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTGS2 |
| Entrez Gene ID | 5743 |
| Ensemble Gene ID | ENSG00000073756 |
| RefSeq Protein Accession(s) | NP_000954.1 |
| RefSeq mRNA Accession(s) | NM_000963.3 |
| UniProt ID(s) | P35354 |
| UniGene ID(s) | Hs.196384 |
| HGNC ID(s) | HGNC:9605 |
| COSMIC ID Link(s) | PTGS2 |
| KEGG Gene ID(s) | hsa:5743 |
| PharmGKB ID(s) | PA293 |
| General Description of Recombinant Human PTGS2 / COX2 / PGHS-2 Protein. | |
| Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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