PDF DatasheetHuman Parathyroid hormone-related protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Parathyroid hormone-related protein based upon sequence from Human
Isoform: Isoform 2
Host: QP6553 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Parathyroid hormone-related protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6553.
Bioactivity Data: Untested
Full Length? Full length of Isoform 2
Expression Region: Ala37 – Arg175
Amino Acid Sequence: AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPSP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTPGKKK KGKPGKRKEQ EKKKRRTRSA WLDSGVTGSG LEGDHLSDTS TTSLELDSR
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Parathyroid hormone-related protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Parathyroid hormone-related protein Protein General Information | |
|---|---|
| Alternate Names | |
| HHM, BDE2, PLP, PTHRP, PTHR | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTHLH |
| Entrez Gene ID | 5744 |
| Ensemble Gene ID | ENSG00000087494 |
| RefSeq Protein Accession(s) | NP_002811.1 |
| RefSeq mRNA Accession(s) | NM_002820.2, NM_198964.1, NM_198965.1, NM_198966.1, XM_011520774.2, XM_011520775.2, XM_017019674.1, XM_017019675.1 |
| UniProt ID(s) | P12272 |
| UniGene ID(s) | Hs.591159 |
| HGNC ID(s) | HGNC:9607 |
| COSMIC ID Link(s) | PTHLH |
| KEGG Gene ID(s) | hsa:5744 |
| PharmGKB ID(s) | PA33952 |
| General Description of Recombinant Human Parathyroid hormone-related protein Protein. | |
| Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows th to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath . Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.1 Publication | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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