PDF DatasheetHuman PTPN6 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PTPN6 based upon sequence from Human
Isoform: Isoform 2
Host: QP6555 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PTPN6, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6555.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Lys597
Amino Acid Sequence: MLSRGVGDQV THIRIQNSGD FYDLYGGEKF ATLTELVEYY TQQQGVLQDR DGTIIHLKYP LNCSDPTSER WYHGHMSGGQ AETLLQAKGE PWTFLVRESL SQPGDFVLSV LSDQPKAGPG SPLRVTHIKV MCEGGRYTVG GLETFDSLTD LVEHFKKTGI EEASGAFVYL RQPYYATRVN AADIENRVLE LNKKQESEDT AKAGFWEEFE SLQKQEVKNL HQRLEGQRPE NKGKNRYKNI LPFDHSRVIL QGRDSNIPGS DYINANYIKN QLLGPDENAK TYIASQGCLE ATVNDFWQMA WQENSRVIVM TTREVEKGRN KCVPYWPEVG MQRAYGPYSV TNCGEHDTTE YKLRTLQVSP LDNGDLIREI WHYQYLSWPD HGVPSEPGGV LSFLDQINQR QESLPHAGPI IVHCSAGIGR TGTIIVIDML MENISTKGLD CDIDIQKTIQ MVRAQRSGMV QTEAQYKFIY VAIAQFIETT KKKLEVLQSQ KGQESEYGNI TYPPAMKNAH AKASRTSSKH KEDVYENLHT KNKREEKVKK QRSADKEKSK GSLKRK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PTPN6 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PTPN6 Protein General Information | |
|---|---|
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTPN6 |
| Entrez Gene ID | 5777 |
| Ensemble Gene ID | ENSG00000111679 |
| RefSeq Protein Accession(s) | NP_002822.2 |
| RefSeq mRNA Accession(s) | NM_002831.5, NM_080548.4, NM_080549.3, XM_011520988.1 |
| UniProt ID(s) | P29350 |
| UniGene ID(s) | Hs.63489 |
| HGNC ID(s) | HGNC:9658 |
| COSMIC ID Link(s) | PTPN6 |
| KEGG Gene ID(s) | hsa:5777 |
| PharmGKB ID(s) | PA34002 |
| General Description of Recombinant Human PTPN6 Protein. | |
| Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hatopoiesis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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