PDF DatasheetHuman PTPRB Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant PTPRB based upon sequence from Human
Host: QP6556 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PTPRB, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6556.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Arg1643 – His1997
Amino Acid Sequence: RQKVSHGRER PSARLSIRRD RPLSVHLNLG QKGNRKTSCP IKINQFEGHF MKLQADSNYL LSKEYEELKD VGRNQSCDIA LLPENRGKNR YNNILPYDAT RVKLSNVDDD PCSDYINASY IPGNNFRREY IVTQGPLPGT KDDFWKMVWE QNVHNIVMVT QCVEKGRVKC DHYWPADQDS LYYGDLILQM LSESVLPEWT IREFKICGEE QLDAHRLIRH FHYTVWPDHG VPETTQSLIQ FVRTVRDYIN RSPGAGPTVV HCSAGVGRTG TFIALDRILQ QLDSKDSVDI YGAVHDLRLH RVHMVQTECQ YVYLHQCVRD VLRARKLRSE QENPLFPIYE NVNPEYHRDP VYSRH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human PTPRB Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human PTPRB Protein General Information | |
|---|---|
| Alternate Names | |
| HPTPB, VEPTP, PTPB, R-PTP-BETA, HPTP-BETA, Receptor-type tyrosine-protein phosphatase be | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTPRB |
| Entrez Gene ID | 5787 |
| Ensemble Gene ID | ENSG00000127329 |
| RefSeq Protein Accession(s) | NP_001103224.1 |
| RefSeq mRNA Accession(s) | NM_001109754.3, NM_001206971.2, NM_001206972.2, NM_001330204.1, NM_002837.5 |
| UniProt ID(s) | P23467 |
| UniGene ID(s) | Hs.201030 |
| HGNC ID(s) | HGNC:9665 |
| COSMIC ID Link(s) | PTPRB |
| KEGG Gene ID(s) | hsa:5787 |
| PharmGKB ID(s) | PA34010 |
| General Description of Recombinant Human PTPRB Protein. | |
| Plays an important role in blood vessel rodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and rodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel rodeling during bryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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