PDF DatasheetHuman CD155 / PVR Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant CD155 / PVR based upon sequence from Human
Host: QP6559 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD155 / PVR, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6559.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Trp21 – Asn343
Amino Acid Sequence: WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human CD155 / PVR Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human CD155 / PVR Protein General Information | |
|---|---|
| Alternate Names | |
| CD155, PVR, D7Ertd458e, 3830421F03Rik, mE4, Tage4, CD155, necl-5, PVS, HVED, Taa1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PVR |
| Entrez Gene ID | 5817 |
| Ensemble Gene ID | ENSG00000073008 |
| RefSeq Protein Accession(s) | NP_001129240.1 |
| RefSeq mRNA Accession(s) | NM_001135768.2, NM_001135769.2, NM_001135770.3, NM_006505.4 |
| UniProt ID(s) | P15151 |
| UniGene ID(s) | Hs.171844 |
| HGNC ID(s) | HGNC:9705 |
| COSMIC ID Link(s) | PVR |
| KEGG Gene ID(s) | hsa:5817 |
| PharmGKB ID(s) | PA34050 |
| General Description of Recombinant Human CD155 / PVR Protein. | |
| Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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