PDF DatasheetHuman Glutaminyl cyclase / QPCT Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Glutaminyl cyclase / QPCT based upon sequence from Human
Host: QP6564 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Glutaminyl cyclase / QPCT, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6564.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Val29 – Leu361
Amino Acid Sequence: VSPSASAWPE EKNYHQPAIL NSSALRQIAE GTSISEMWQN DLQPLLIERY PGSPGSYAAR QHIMQRIQRL QADWVLEIDT FLSQTPYGYR SFSNIISTLN PTAKRHLVLA CHYDSKYFSH WNNRVFVGAT DSAVPCAMML ELARALDKKL LSLKTVSDSK PDLSLQLIFF DGEEAFLHWS PQDSLYGSRH LAAKMASTPH PPGARGTSQL HGMDLLVLLD LIGAPNPTFP NFFPNSARWF ERLQAIEHEL HELGLLKDHS LEGRYFQNYS YGGVIQDDHI PFLRRGVPVL HLIPSPFPEV WHTMDDNEEN LDESTIDNLN KILQVFVLEY LHL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Glutaminyl cyclase / QPCT Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Glutaminyl cyclase / QPCT Protein General Information | |
|---|---|
| Alternate Names | |
| Glutaminyl cyclase, QPCT, GCT, sQC, QC | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | QPCT |
| Entrez Gene ID | 25797 |
| Ensemble Gene ID | ENSG00000115828 |
| RefSeq Protein Accession(s) | NP_036545.1 |
| RefSeq mRNA Accession(s) | NM_012413.3 |
| UniProt ID(s) | Q16769 |
| UniGene ID(s) | Hs.79033 |
| HGNC ID(s) | HGNC:9753 |
| COSMIC ID Link(s) | QPCT |
| KEGG Gene ID(s) | hsa:25797 |
| PharmGKB ID(s) | PA34095 |
| General Description of Recombinant Human Glutaminyl cyclase / QPCT Protein. | |
| Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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