PDF DatasheetHuman Ras-related protein Rab-11A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ras-related protein Rab-11A based upon sequence from Human
Host: QP6566 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ras-related protein Rab-11A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6566.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gly2 – Cys213
Amino Acid Sequence: GTRDDEYDYL FKVVLIGDSG VGKSNLLSRF TRNEFNLESK STIGVEFATR SIQVDGKTIK AQIWDTAGQE RYRAITSAYY RGAVGALLVY DIAKHLTYEN VERWLKELRD HADSNIVIML VGNKSDLRHL RAVPTDEARA FAEKNGLSFI ETSALDSTNV EAAFQTILTE IYRIVSQKQM SDRRENDMSP SNNVVPIHVP PTTENKPKVQ CC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Ras-related protein Rab-11A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ras-related protein Rab-11A Protein General Information | |
|---|---|
| Alternate Names | |
| YL8 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAB11A |
| Entrez Gene ID | 8766 |
| Ensemble Gene ID | ENSG00000103769 |
| RefSeq Protein Accession(s) | NP_001193765.1 |
| RefSeq mRNA Accession(s) | NM_001206836.1, NM_004663.4 |
| UniProt ID(s) | P62491 |
| UniGene ID(s) | Hs.321541 |
| HGNC ID(s) | HGNC:9760 |
| COSMIC ID Link(s) | RAB11A |
| KEGG Gene ID(s) | hsa:8766 |
| PharmGKB ID(s) | PA34101 |
| General Description of Recombinant Human Ras-related protein Rab-11A Protein. | |
| The small GTPases Rab are key regulators of intracellular mbrane trafficking, from the formation of transport vesicles to their fusion with mbranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to mbranes different set of downstream effectors directly responsible for vesicle formation, movent, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of mbrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical mbrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma mbrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma mbrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma mbrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral mbranes. May also play a role in melanosome transport and release from melanocytes. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.