PDF DatasheetHuman UV excision repair protein RAD23 homolog A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant UV excision repair protein RAD23 homolog A based upon sequence from Human
Host: QP6578 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) UV excision repair protein RAD23 homolog A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6578.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Glu363
Amino Acid Sequence: MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP IRDYRIDEKN FVVVMVTKTK AGQGTSAPPE ASPTAAPESS TSFPPAPTSG MSHPPPAARE DKSPSEESAP TTSPESVSGS VPSSGSSGRE EDAASTLVTG SEYETMLTEI MSMGYERERV VAALRASYNN PHRAVEYLLT GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ FQNMRQVIQQ NPALLPALLQ QLGQENPQLL QQISRHQEQF IQMLNEPPGE LADISDVEGE VGAIGEEAPQ MNYIQVTPQE KEAIERLKAL GFPESLVIQA YFACEKNENL AANFLLSQNF DDE
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human UV excision repair protein RAD23 homolog A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human UV excision repair protein RAD23 homolog A Protein General Information | |
|---|---|
| Alternate Names | |
| HHR23A, HR23A | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAD23A |
| Entrez Gene ID | 5886 |
| Ensemble Gene ID | ENSG00000179262 |
| RefSeq Protein Accession(s) | NP_001257291.1 |
| RefSeq mRNA Accession(s) | NM_001270362.1, NM_001270363.1, NM_005053.3 |
| UniProt ID(s) | P54725 |
| UniGene ID(s) | Hs.643267 |
| HGNC ID(s) | HGNC:9812 |
| COSMIC ID Link(s) | RAD23A |
| KEGG Gene ID(s) | hsa:5886 |
| PharmGKB ID(s) | PA34172 |
| General Description of Recombinant Human UV excision repair protein RAD23 homolog A Protein. | |
| Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ‘Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ‘Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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