PDF DatasheetHuman DNA repair protein RAD51 homolog 4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA repair protein RAD51 homolog 4 based upon sequence from Human
Host: QP6579 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA repair protein RAD51 homolog 4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6579.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: MGVLRVGLCP GLTEEMIQLL RSHRIKTVVD LVSADLEEVA QKCGLSYKAL VALRRVLLAQ FSAFPVNGAD LYEELKTSTA ILSTGIGSLD KLLDAGLYTG EVTEIVGGPG SGKTQVCLCM AANVAHGLQQ NVLYVDSNGG LTASRLLQLL QAKTQDEEEQ AEALRRIQVV HAFDIFQMLD VLQELRGTVA QQVTGSSGTV KVVVVDSVTA VVSPLLGGQQ REGLALMMQL ARELKTLARD LGMAVVVTNH ITRDRDSGRL KPALGRSWSF VPSTRILLDT IEGAGASGGR RMACLAKSSR QPTGFQEMVD IGTWGTSEQS ATLQGDQT
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human DNA repair protein RAD51 homolog 4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA repair protein RAD51 homolog 4 Protein General Information | |
|---|---|
| Alternate Names | |
| BROVCA4, R51H3, RAD51L3, TRAD | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAD51L3 |
| Entrez Gene ID | 5892 |
| Ensemble Gene ID | ENSG00000185379 |
| RefSeq Protein Accession(s) | NP_001136043.1 |
| RefSeq mRNA Accession(s) | NM_001142571.1, NM_002878.3, NM_133629.2 |
| UniProt ID(s) | O75771 |
| UniGene ID(s) | Hs.631757 |
| HGNC ID(s) | HGNC:9823 |
| KEGG Gene ID(s) | hsa:5892 |
| PharmGKB ID(s) | PA34179 |
| General Description of Recombinant Human DNA repair protein RAD51 homolog 4 Protein. | |
| Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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