PDF DatasheetHuman GTP-binding nuclear protein Ran Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant GTP-binding nuclear protein Ran based upon sequence from Human
Host: QP6583 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) GTP-binding nuclear protein Ran, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6583.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: AAQGEPQVQF KLVLVGDGGT GKTTFVKRHL TGEFEKKYVA TLGVEVHPLV FHTNRGPIKF NVWDTAGQEK FGGLRDGYYI QAQCAIIMFD VTSRVTYKNV PNWHRDLVRV CENIPIVLCG NKVDIKDRKV KAKSIVFHRK KNLQYYDISA KSNYNFEKPF LWLARKLIGD PNLEFVAMPA LAPPEVVMDP ALAAQYEHDL EVAQTTALPD EDDDL
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human GTP-binding nuclear protein Ran Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human GTP-binding nuclear protein Ran Protein General Information | |
|---|---|
| Alternate Names | |
| ARA24, Gsp1, TC4 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RAN |
| Entrez Gene ID | 5901 |
| Ensemble Gene ID | ENSG00000132341 |
| RefSeq Protein Accession(s) | NP_001287725.1 |
| RefSeq mRNA Accession(s) | NM_001300796.1, NM_001300797.1, NM_006325.4 |
| UniProt ID(s) | P62826 |
| UniGene ID(s) | Hs.10842 |
| HGNC ID(s) | HGNC:9846 |
| COSMIC ID Link(s) | RAN |
| KEGG Gene ID(s) | hsa:5901 |
| PharmGKB ID(s) | PA34205 |
| General Description of Recombinant Human GTP-binding nuclear protein Ran Protein. | |
| GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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