PDF DatasheetHuman Regulator of G-protein signaling 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Regulator of G-protein signaling 2 based upon sequence from Human
Host: QP6603 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Regulator of G-protein signaling 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6603.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Thr211
Amino Acid Sequence: MQSAMFLAVQ HDCRPMDKSA GSGHKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT GKKSKQQAFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Regulator of G-protein signaling 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Regulator of G-protein signaling 2 Protein General Information | |
|---|---|
| Alternate Names | |
| G0S8 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RGS2 |
| Entrez Gene ID | 5997 |
| Ensemble Gene ID | ENSG00000116741 |
| RefSeq Protein Accession(s) | NP_002914.1 |
| RefSeq mRNA Accession(s) | NM_002923.3 |
| UniProt ID(s) | P41220 |
| UniGene ID(s) | Hs.78944 |
| HGNC ID(s) | HGNC:9998 |
| COSMIC ID Link(s) | RGS2 |
| KEGG Gene ID(s) | hsa:5997 |
| PharmGKB ID(s) | PA34372 |
| General Description of Recombinant Human Regulator of G-protein signaling 2 Protein. | |
| Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving th into their inactive GDP-bound form. May play a role in leukogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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