PDF DatasheetHuman E3 ubiquitin-protein ligase RNF114 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase RNF114 based upon sequence from Human
Host: QP6611 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase RNF114, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6611.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Gln228
Amino Acid Sequence: MAAQQRDCGG AAQLAGPAAE ADPLGRFTCP VCLEVYEKPV QVPCGHVFCS ACLQECLKPK KPVCGVCRSA LAPGVRAVEL ERQIESTETS CHGCRKNFFL SKIRSHVATC SKYQNYIMEG VKATIKDASL QPRNVPNRYT FPCPYCPEKN FDQEGLVEHC KLFHSTDTKS VVCPICASMP WGDPNYRSAN FREHIQRRHR FSYDTFVDYD VDEEDMMNQV LQRSIIDQ
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human E3 ubiquitin-protein ligase RNF114 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human E3 ubiquitin-protein ligase RNF114 Protein General Information | |
|---|---|
| Alternate Names | |
| ZNF313, PSORS12 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RNF114 |
| Entrez Gene ID | 55905 |
| Ensemble Gene ID | ENSG00000124226 |
| RefSeq Protein Accession(s) | NP_061153.1 |
| RefSeq mRNA Accession(s) | NM_018683.3 |
| UniProt ID(s) | Q9Y508 |
| UniGene ID(s) | Hs.144949 |
| HGNC ID(s) | HGNC:13094 |
| COSMIC ID Link(s) | RNF114 |
| KEGG Gene ID(s) | hsa:55905 |
| PharmGKB ID(s) | PA162401502 |
| General Description of Recombinant Human E3 ubiquitin-protein ligase RNF114 Protein. | |
| E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle’s G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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