PDF DatasheetHuman RING-box protein 2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant RING-box protein 2 based upon sequence from Human
Host: QP6613 protein expressed in E.coli, Yeast..
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) RING-box protein 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6613.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ala2 – Lys113
Amino Acid Sequence: ADVEDGEETC ALASHSGSSG SKSGGDKMFS LKKWNAVAMW SWDVECDTCA ICRVQVMDAC LRCQAENKQE DCVVVWGECN HSFHNCCMSL WVKQNNRCPL CQQDWVVQRI GK
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human RING-box protein 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human RING-box protein 2 Protein General Information | |
|---|---|
| Alternate Names | |
| CKBBP1, ROC2, SAG | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | RNF7 |
| Entrez Gene ID | 9616 |
| Ensemble Gene ID | ENSG00000114125 |
| RefSeq Protein Accession(s) | NP_001188299.1 |
| RefSeq mRNA Accession(s) | NM_001201370.1, NM_014245.4, NM_183237.2 |
| UniProt ID(s) | Q9UBF6 |
| UniGene ID(s) | Hs.134623 |
| HGNC ID(s) | HGNC:10070 |
| COSMIC ID Link(s) | RNF7 |
| KEGG Gene ID(s) | hsa:9616 |
| PharmGKB ID(s) | PA34444 |
| General Description of Recombinant Human RING-box protein 2 Protein. | |
| Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, ses to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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