PDF DatasheetHuman S100A12 / CAGC / Calgranulin-C Protein Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant S100A12 / CAGC / Calgranulin-C Protein based upon sequence from Human
Host: QP6637 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) S100A12 / CAGC / Calgranulin-C Protein, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6637.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL DANQDEQVDF QEFISLVAIA LKAAHYHTHK E
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human S100A12 / CAGC / Calgranulin-C Protein Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human S100A12 / CAGC / Calgranulin-C Protein Protein General Information | |
|---|---|
| Alternate Names | |
| S100A12, CAGC, Calgranulin-C Protein, p6, CAAF1, MRP6, CAGC, CGRP, ENRAGE, MRP-6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | S100A12 |
| Entrez Gene ID | 6283 |
| Ensemble Gene ID | ENSG00000163221 |
| RefSeq Protein Accession(s) | NP_005612.1 |
| RefSeq mRNA Accession(s) | NM_005621.1 |
| UniProt ID(s) | P80511 |
| UniGene ID(s) | Hs.19413 |
| HGNC ID(s) | HGNC:10489 |
| COSMIC ID Link(s) | S100A12 |
| KEGG Gene ID(s) | hsa:6283 |
| PharmGKB ID(s) | PA34901 |
| General Description of Recombinant Human S100A12 / CAGC / Calgranulin-C Protein Protein. | |
| S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.