PDF DatasheetHuman SIRP alpha / CD172a Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SIRP alpha / CD172a based upon sequence from Human
Host: QP6684 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SIRP alpha / CD172a, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6684.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Glu31 – Tyr373
Amino Acid Sequence: EEELQVIQPD KSVLVAAGET ATLRCTATSL IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT AAENTGSNER NIY
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human SIRP alpha / CD172a Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SIRP alpha / CD172a Protein General Information | |
|---|---|
| Alternate Names | |
| SIRP alpha, CD172a, Bit, SHPS-1, SIRP, P84, AI835480, SHP-1, CD172a, Ptpns1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SIRPA |
| Entrez Gene ID | 140885 |
| Ensemble Gene ID | ENSG00000198053 |
| RefSeq Protein Accession(s) | NP_001035111.1 |
| RefSeq mRNA Accession(s) | NM_001040022.1, NM_001040023.1, NM_001330728.1, NM_080792.2, XM_005260670.3 |
| UniProt ID(s) | P78324 |
| UniGene ID(s) | Hs.581021 |
| HGNC ID(s) | HGNC:9662 |
| COSMIC ID Link(s) | SIRPA |
| KEGG Gene ID(s) | hsa:140885 |
| PharmGKB ID(s) | PA34006 |
| General Description of Recombinant Human SIRP alpha / CD172a Protein. | |
| Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma mbrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function . Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
There are no reviews yet.