PDF DatasheetHuman SMARCA2 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SMARCA2 based upon sequence from Human
Host: QP6698 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) SMARCA2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6698.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser700 – Phe1216
Amino Acid Sequence: SYYTVAHAIS ERVEKQSALL INGTLKHYQL QGLEWMVSLY NNNLNGILAD EMGLGKTIQT IALITYLMEH KRLNGPYLII VPLSTLSNWT YEFDKWAPSV VKISYKGTPA MRRSLVPQLR SGKFNVLLTT YEYIIKDKHI LAKIRWKYMI VDEGHRMKNH HCKLTQVLNT HYVAPRRILL TGTPLQNKLP ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGERVDLNEE ETILIIRRLH KVLRPFLLRR LKKEVESQLP EKVEYVIKCD MSALQKILYR HMQAKGILLT DGSEKDKKGK GGAKTLMNTI MQLRKICNHP YMFQHIEESF AEHLGYSNGV INGAELYRAS GKFELLDRIL PKLRATNHRV LLFCQMTSLM TIMEDYFAFR NFLYLRLDGT TKSEDRAALL KKFNEPGSQY FIFLLSTRAG GLGLNLQAAD TVVIFDSDWN PHQDLQAQDR AHRIGQQNEV RVLRLCTVNS VEEKILAAAK YKLNVDQKVI QAGMFDQKSS SHERRAF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human SMARCA2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human SMARCA2 Protein General Information | |
|---|---|
| Alternate Names | |
| BAF190, SNF2L2, SNF2, SWI2, Sth1p, hBRM, hSNF2a, NCBRS, BRM, SNF2LA, Probable global transcription activator SNF2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SMARCA2 |
| Entrez Gene ID | 6595 |
| Ensemble Gene ID | ENSG00000080503 |
| RefSeq Protein Accession(s) | NP_001276325.1 |
| RefSeq mRNA Accession(s) | NM_001289396.1, NM_001289397.1, NM_003070.4, NM_139045.3 |
| UniProt ID(s) | P51531 |
| UniGene ID(s) | Hs.298990 |
| HGNC ID(s) | HGNC:11098 |
| COSMIC ID Link(s) | SMARCA2 |
| KEGG Gene ID(s) | hsa:6595 |
| PharmGKB ID(s) | PA35948 |
| General Description of Recombinant Human SMARCA2 Protein. | |
| Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a postmitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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