PDF DatasheetHuman Suppressor of cytokine signaling 1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Suppressor of cytokine signaling 1 based upon sequence from Human
Host: QP6711 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Suppressor of cytokine signaling 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6711.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ile211
Amino Acid Sequence: MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ RIVATVGREN LARIPLNPVL RDYLSSFPFQ I
Purity: Greater than 91.1% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Suppressor of cytokine signaling 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Suppressor of cytokine signaling 1 Protein General Information | |
|---|---|
| Alternate Names | |
| CIS1, CISH1, JAB, SSI1, SOCS-1, SSI-1, TIP3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SOCS1 |
| Entrez Gene ID | 8651 |
| Ensemble Gene ID | ENSG00000185338 |
| RefSeq Protein Accession(s) | NP_003736.1 |
| RefSeq mRNA Accession(s) | NM_003745.1 |
| UniProt ID(s) | O15524 |
| UniGene ID(s) | Hs.50640 |
| HGNC ID(s) | HGNC:19383 |
| COSMIC ID Link(s) | SOCS1 |
| KEGG Gene ID(s) | hsa:8651 |
| PharmGKB ID(s) | PA134863068 |
| General Description of Recombinant Human Suppressor of cytokine signaling 1 Protein. | |
| SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival . Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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