PDF DatasheetRat Suppressor of cytokine signaling 3 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Suppressor of cytokine signaling 3 based upon sequence from Rat
Host: QP6713 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Suppressor of cytokine signaling 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6713.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Leu225
Amino Acid Sequence: MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL SAEPAGTFLI RDSSDQRHFF TLSVETQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV LKLVHHYMPP PGAPSFSLPP TEPSFEVQEQ PPAQALPGGT PKRAYYIYSG GEKIPLVLSR PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat Suppressor of cytokine signaling 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Suppressor of cytokine signaling 3 Protein General Information | |
|---|---|
| Alternate Names | |
| Socs-3, Ssi-3, Cish3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Socs3 |
| Entrez Gene ID | 89829 |
| RefSeq Protein Accession(s) | NP_446017.1 |
| RefSeq mRNA Accession(s) | NM_053565.1 |
| UniProt ID(s) | O88583 |
| UniGene ID(s) | Rn.127801 |
| COSMIC ID Link(s) | Socs3 |
| KEGG Gene ID(s) | rno:89829 |
| General Description of Recombinant Rat Suppressor of cytokine signaling 3 Protein. | |
| SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize IL6ST . | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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