PDF DatasheetRat Sortilin Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Sortilin based upon sequence from Rat
Host: QP6716 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Rattus norvegicus (Rat) Sortilin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6716.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Cys610 – Ser754
Amino Acid Sequence: CEENDYTTWL AHSTDPGDYK DGCILGYKEQ FLRLRKSSVC QNGRDYVVAK QPSICPCSLE DFLCDFGYFR PENASECVEQ PELKGHELEF CLYGKEEHLT TNGYRKIPGD RCQGGMNPAR EVKDLKKKCT SNFLNPKKQN SKSSS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Rat Sortilin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Rat Sortilin Protein General Information | |
|---|---|
| Alternate Names | |
| Nts3, Nt3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Sort1 |
| Entrez Gene ID | 83576 |
| Ensemble Gene ID | ENSRNOG00000031814 |
| RefSeq Protein Accession(s) | NP_113955.1 |
| RefSeq mRNA Accession(s) | NM_031767.1 |
| UniProt ID(s) | O54861 |
| UniGene ID(s) | Rn.11286 |
| COSMIC ID Link(s) | Sort1 |
| KEGG Gene ID(s) | rno:83576 |
| General Description of Recombinant Rat Sortilin Protein. | |
| Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the Extracellular domain matrix during osteogenic differentiation by scavenging Extracellular domain LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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