PDF DatasheetHuman Synaptotagmin-1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Synaptotagmin-1 based upon sequence from Human
Host: QP6757 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Synaptotagmin-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6757.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Lys99 – Ala416
Amino Acid Sequence: KNAINMKDVK DLGKTMKDQA LKDDDAETGL TDGEEKEEPK EEEKLGKLQY SLDYDFQNNQ LLVGIIQAAE LPALDMGGTS DPYVKVFLLP DKKKKFETKV HRKTLNPVFN EQFTFKVPYS ELGGKTLVMA VYDFDRFSKH DIIGEFKVPM NTVDFGHVTE EWRDLQSAEK EEQEKLGDIC FSLRYVPTAG KLTVVILEAK NLKKMDVGGL SDPYVKIHLM QNGKRLKKKK TTIKKNTLNP YYNESFSFEV PFEQIQKVQV VVTVLDYDKI GKNDAIGKVF VGYNSTGAEL RHWSDMLANP RRPIAQWHTL QVEEEVDA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Synaptotagmin-1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Synaptotagmin-1 Protein General Information | |
|---|---|
| Alternate Names | |
| SVP65, SYT, P65 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | SYT1 |
| Entrez Gene ID | 6857 |
| Ensemble Gene ID | ENSG00000067715 |
| RefSeq Protein Accession(s) | NP_001129277.1 |
| RefSeq mRNA Accession(s) | NM_001135805.1, NM_001135806.1, NM_005639.2, XM_011538710.1, XM_017019909.1 |
| UniProt ID(s) | P21579 |
| UniGene ID(s) | Hs.310545 |
| HGNC ID(s) | HGNC:11509 |
| COSMIC ID Link(s) | SYT1 |
| KEGG Gene ID(s) | hsa:6857 |
| PharmGKB ID(s) | PA36290 |
| General Description of Recombinant Human Synaptotagmin-1 Protein. | |
| May have a regulatory role in the mbrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca2+-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca2+-independent manner; these are neurexins, syntaxin and AP2. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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